منابع مشابه
Dual mechanism mediating opiate effects?
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Introduction: Radiation Induced Bystander Effect (RIBE) which cause radiation effects in non-irradiated cells, has challenged the principle according to which radiation traversal through the nucleus of a cell is necessary for producing biological responses. What is the mechanism of this phenomenon? To have a better understanding of this rather ambiguous concept substantial number of original ...
متن کاملDual Mechanism of Action
The effect of ouabain on exocytotic and nonexocytotic norepinephrine release was investigated in perfused rat and guinea pig hearts. The overflow of endogenous norepinephrine and its neuronal metabolite 3,4-dihydroxyphenylethyleneglycol (DOPEG) was determined by highpressure liquid chromatography. DOPEG served as the indicator of free axoplasmic norepinephrine concentrations. The overflow of th...
متن کاملDeprivation state switches the neurobiological substrates mediating opiate reward in the ventral tegmental area.
The population of mesolimbic dopaminergic neurons is believed to be a primary site at which opiates produce their rewarding effects. Using an unbiased, counterbalanced place conditioning paradigm, we reexamined the contribution made by these cells to the rewarding properties of morphine. Rats were conditioned such that distinct environments were paired with an intra-ventral tegmental area (VTA)...
متن کاملWhite's effect: a dual mechanism.
White (1979) has described a phenomenon in which grey bars replacing segments of the white phase of a square-wave grating appear darker than identical grey bars replacing segments of the black phase of the grating. We have investigated the properties of this effect with a view to discovering the underlying mechanisms. Four experiments are reported which reveal the effects of the heights and wid...
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ژورنال
عنوان ژورنال: Science
سال: 1979
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.205.4404.424